Your thalamus is a club bouncer

Having a little trouble waking up this morning? Perhaps your brain stem isn't transmitting enough nitric oxide to your thalamus ...

As we yawn and open our eyes in the morning, the brain stem sends little puffs of nitric oxide to another part of the brain, the thalamus, which then directs it elsewhere.

Like a computer booting up its operating system before running more complicated programs, the nitric oxide triggers certain functions that set the stage for more complex brain functions, according to a new study.

Let me pause the article for a moment and say that I am one of those weirdos who has always been able to wake up early in the morning, and wake up wide awake. I inherited this from both parents; my mother would pop out of bed at 5 a.m. intense and focused; my father was at the refinery before 7 a.m. throughout his working career. I have become even more pronounced in this pattern as I've gotten older (witness many of my postings here as evidence). Furthermore, it took me a long time to understand that I am the exception compared to most other people. I spent quite a few years being harsh on those with whom I shared living arrangements -- siblings, roommates, spouse -- who could sleep soundly until noon. (Frankly, most of my life I thought they were simply lazy.)

In these first moments of the day, sensory information floods the system—the bright sunlight coming through the curtains, the time on the screeching alarm clock—and all of it needs to be processed and organized, so the brain can understand its surroundings and begin to perform more complex tasks.

"The thinking part of the brain is applying a sort of stencil to the information coming in and what the nitric oxide is doing is allowing more refinement of that stencil," says Dwayne Godwin, an associate professor at Wake Forest University and lead author of the study, which was funded by the National Eye Institute.

The little two-atom molecule, it seems, is partly responsible for our ability to perceive whatever it is we're sensing.

...

The thalamus was thought to be a fairly primitive structure, sort of a gate that could either open and allow sensory information to stream into the cortex, the higher functioning part of the brain, or cut off the flow entirely.

Godwin says the new research shows it's more accurate to think of the thalamus not as a gate but as a club bouncer, who doesn't simply allow a huge rush of people to go in or no one at all, but picks and chooses whom to let in and out.

"Instead of vision being a process going straight from eye to cortex, it's more of a loop," Godwin explained. "This constitutes a new role for the thalamus in directing, not just modulating."

While this study is the first to identify nitric oxide's role in the thalamus, elsewhere in the body it was already known to have an important, if somewhat different function. The molecule is actually integral to controlling blood flow and is, in fact, the molecule Viagra targets in order to increase blood flow to the penis.

The teeny molecule might have other medical uses.

"This study shows a unique role for nitric oxide. It may help us to someday understand what goes wrong in diseases that affect cognitive processing, such as attention deficit disorder or schizophrenia, and it adds to our fundamental understanding of how we perceive the world around us," Godwin said.

The club bouncer uses Viagra. Well, he's so obese that I guess he has to. What a simultaneously compelling and repulsive visual (within my own personal subcortex, of course).

There might be more postings today live from Camp Wellstone, as I can find a few moments. There are about sixty or so of us in attendance, most from Houston and elsewhere in Texas but also an independent candidate from Oklahoma, a guy whose family owns a restaurant in Chicago and a New York author of erotica.

You're all on notice!

Create your own at this link.

Barbara vs. Kay, Camp Wellstone, Fire Thunder and Feingold

The Dallas Women Lawyers Association confirms that Barbara Radnofsky will debate Kay Bailey Hutchison on Friday evening, September 29, at 6 p.m. at Dallas' Belo Mansion.

I'll be attending Camp Wellstone this weekend, as well as ROADWomen's Fork in the Road dinner on Saturday, which features Cecelia Fire Thunder as guest speaker.

And Senator Russ Feingold will headline the Harris County Democratic Party's Johnson-Rayburn Dinner, to be held Saturday, September 30, at the JW Marriott here.

Congratulations also to Jamaal Smith and Sandra Puente on their new gigs at the HCDP.

Jocularity! Jocularity!

This is a photograph of former Ohio State football hero Maurice Clarett's front seat, after he was arrested in a standoff with police in which he was first Tasered, then Maced because the Taser didn't work (he had on a bulletproof vest):


Only one observation:

When you finna throw down on tha playa-hatahs, it's important to be lint-free.

I found this while bumping around in Ted Stevens' tubes. It's a mock-out of both Star Trek and those inspirational posters that have been around for a few decades now:


There are many more here.

Texroots Tuesday

Chris Bell and Maria Luisa Alvarado are traveling together through the Rio Grande Valley the next few days.

Supreme Court Justice nominee Bill Moody started his walk across Texas this week; Land Commissioner candidate VaLinda Hathcox has joined him. (See photos here and here.)

David Van Os continues his Whistlestop Tour to county courthouses in North Texas (Comanche and Archer City and Wichita Falls) and West Texas (Albany and Sweetwater and San Angelo).

And the inaugural trio of Texroots-endorsed Democrats still need a little juice from you. Here's an excellent Q&A on what the Texroots are all about, and here's more on Hank, Shane, and Juan, courtesy of Vince Leibowitz at Capitol Annex:

Juan Garcia. [Website, Bio, Volunteer] Juan Garcia is running against entrenched Craddickat incumbent Gene Seaman (R-Corpus Christi). This is one of a hand-full of races that can be “flipped” from Republican to Democratic control this fall. While Seaman has a massive warchest on hand from previous election cycles, Garcia is actually leading the incumbent in fund-raising right now. To boot, he’s flipped a number of Seaman’s contributors and supporters who are tired of this district being in the hands of someone who is more concerned with staying in Tom Craddick’s good graces than serving the people. And, who could forget Seaman’s vacation to his home-away-from-home in Vail.

Here are some other good Garcia coverage: Why You Should Vote For Juan Garcia (South Texas Chisme), Where In The World Is Gene Seaman (CapitolAnnex), Juan Garcia vs. The Culture of Corruption (Truth Serum Blog), Gene Seaman Is Already Running Scared (The Red State), Juan Garcia Conference Call (CapitolAnnex).

Shane Sklar. [Website, Bio, Volunteer] At 30, Shane Sklar has already headed one of the state’s largest agriculture groups and made a name for himself in the agriculture community. Now, he’s seeking to unseat failed Libertarian Presidential Candidate turned Republican Congressman Ron Paul (R-Surfside) to give the people of Congressional District 14 effective representation. Paul’s main pet projects including voting against nearly every piece of legislation he has the opportunity to vote against—including aide for parts of Texas ravaged by Hurricane Katrina—and bemoaning the fact that the U.S. is no longer on the “gold standard.” Polling in the district earlier this year shows that voters are dissatisfied with Paul’s “Dr. No” attitude and his failure to support legislation that would benefit the district.

Here are some other links related to Shane Sklar: Guest Post at Off The Kuff, Interview with Shane Sklar (via Kuff, mp3), Sklar blasts Paul for voting against Relief (Baytown Sun), Captain Ron (In The Pink Texas), Interview with Shane Sklar (AustinNews.net), Bad Poll Numbers for Ron Paul (Kuff’s World).

Hank Gilbert. [Website, Bio, Volunteer] Remember Todd Staples (R-Palestine)? The State Senator who was one of the architects of DeLay’s redistricting scheme and is one of the Trans Texas Corridor’s best friends in the Legislature? He’s now running for Agriculture Commissioner, although no one can quite point to any major achievements he made for agricluture while in the Texas Senate. Hank Gilbert is a rancher and former high school ag teacher who actually wants to be agriculture commissioner, instead of simply use the post as a stepping-stone to higher office, like Leininger devotee Susan Combs. Hank’s fierce opposition to the Trans Texas Corridor and his common-sense goals for the Texas Department of Agriculture are far more suited to a state that boasts such an important agribusiness economy than those of his opponent.

Here are some links on Hank (or, in the case of the first link, against his opponent): Don’t Get Stapled, Hank Gilbert Or Corporate Interests–You Choose (Jobsanger), Hank Gilbert For Ag Commissioner (Burnt Orange Report), Hank Gilbert, 40/40 Project (Burnt Orange Report), Hank Gilbert: Candidate for Ag Commissioner has Better Solution (The Open Road [note: this is an anti-toll road blog, not a progressive “D” blog, but I thought it added some variety to this list), Interview with Hank Gilbert (mp3, via Off The Kuff).

So…what are you waiting for? Click here to support these three great candidates! You can split your donation among all three candidates or make separate donations to each campaign.

Update: The Blogging Representative has a report with photos of the Governor and Lieutenant Governor in the Valley. And I wish to express a humble 'thank you' to all who helped push David Van Os over the top in his "$30,000 in thirty days" fundraising appeal. (Note also the graphic in the right sidebar.)